Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 22, Issue 19, Pages 3061-3068Publisher
WILEY
DOI: 10.1002/rcm.3708
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Funding
- National High Technology Research and Development [2006AA02Z4C5]
- National Natural Science Foundation of Chin [30600739, 30772505]
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The purpose of this study was to investigate the serum metabolic difference between hepatocellular carcinoma (HCC, n = 20) male patients and normal male subjects (n = 20). Serum metabolome was detected through chemical derivatization followed by gas chromatography/mass spectrometry (GC/ MS). The acquired GC/MS data was analyzed by stepwise discriminant analysis (SDA) and support vector machine (SVM). The metabolites including butanoic acid, ethanimidic acid, glycerol, Lisoleucine, L-valine, aminomalonic acid, D-erythrose, hexadecanoic acid, octadecanoic acid, and 9,12octadecadienoic acid in combination with each other gave the strongest segregation between the two groups. By applying these variables, our method provided a diagnostic model that could well discriminate between HCC patients and normal subjects. More importantly, the error count estimate for each group was 0%. The total classifying accuracy of the discriminant function tested by SVM 20fold cross validation was 75%. This technique is different from traditional ones and appears to be a useful tool in the area of HCC diagnosis. Copyright (c) 2008 John Wiley & Sons, Ltd.
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