Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 22, Issue 3, Pages 301-313Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/rcm.3370
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We have studied the photocatalytic transformation of atenolol, 4-[2-hydroxy-3-[(l-methyl)amino] propoxyllbenzeneacetamide, a cardioselective beta-blocking agent used to treat cardiac arrhythmias and hypertension, under simulated solar irradiation using titanium dioxide as photocatalyst. The investigation involved monitoring drug decomposition, identifying intermediate compounds, assessing mineralization, and evaluating toxicity. High-performance liquid chromatography (HPLC) coupled to high-resolution mass spectrometry (HRMS) via an electrospray ionization (ESI) interface was a powerful tool for the identification and measurement of the degradation products; 23 main species were identified. Intermediates were characterized through their chromatographic behavior and evolution kinetics, coupled with accurate mass information. Through the full analysis of MS and MSn spectra and a comparison with parent drug fragmentation pathways, the diverse isomers were characterized. Neither atenolol nor the intermediates formed exhibit acute toxicity. All intermediates are easily degraded and no compound identified could withstand 2h irradiation. Photomineralization of the substrate in terms of carbon mineralization and nitrogen release was rapid and, within 4h of irradiation, organic nitrogen and carbon were completely mineralized. Copyright (c) 2008 John Wiley & Sons, Ltd.
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