Journal
RADIOTHERAPY AND ONCOLOGY
Volume 129, Issue 3, Pages 582-588Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2018.08.016
Keywords
Ultra-high dose-rate X-ray radiation; Synchrotron radiation; Cognitive impairment; Radiation-induced brain injury
Funding
- Fond'action lead agency [FNS/ANR CR32I3L_156924]
- ISREC Foundation
- ESRF
- Conseil Regional Rhone-Alpes, la Ligue contre le Cancer, l'Association pour la Recherche contre le Cancer (ARC)
- INCA [PRTK17048]
- Ecole Normale Superieure de Cachan, France (MESR, France)
- FNS (Switzerland) [31003A_156892]
- ISREC Foundation (Switzerland)
- FNS/ANR [CR32I3L_156924]
- ARC (France)
- Linksium SATT (France)
Ask authors/readers for more resources
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis. (C) 2018 Published by Elsevier B.V.
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