Journal
RADIOTHERAPY AND ONCOLOGY
Volume 111, Issue 3, Pages 360-365Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2014.06.001
Keywords
Head and neck cancer; Recurrence; Pattern of failure; FDG-PET; Radiotherapy
Funding
- CIRRO - The Lundbeck Foundation Centre for Interventional Research in Radiation Oncology
- University of Copenhagen
- Danish Graduate School for Clinical Oncology
- Global Excellence in Health program of the Capital Region of Denmark
- National Cancer Institute [P30 CA 134274-04]
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Background and purpose: To analyze the recurrence pattern in relation to target volumes and F-18-fluoro-deoxyglucose (FDG) uptake on positron emission tomography in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive chemoradiation. Material and methods: 520 patients received radiotherapy for HNSCC from 2005 to 2009. Among 100 patients achieving complete clinical response and a later recurrence, 39 patients with 48 loco-regional failures had a recurrence CT scan before any salvage therapy. The estimated point of origin of each recurrence was transferred to the planning CT by deformable image co-registration. The recurrence position was then related to the delineated target volumes and iso-SUV-contours relative to the maximum standard uptake value (SUV). We defined the recurrence density as the total number of recurrences in a sub-volume divided by the sum of that volume for all patients. Results: 54% (95% CI 37-69%) of recurrences originated inside the FDG-positive volume and 96% (95% Cl 86-99%) in the high dose region. Recurrence density was significantly higher in the central target volumes (P < 0.0001) and increased with increasing FDG avidity (P = 0.036). Conclusions: The detailed pattern-of-failure data analysis suggests that most recurrences occur in the FDG PET positive areas or the solid tumor. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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