Journal
RADIOTHERAPY AND ONCOLOGY
Volume 110, Issue 1, Pages 137-143Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2014.01.005
Keywords
Radiation therapy; Skin reactions; Moist desquamation; RISRAS; Mepitel Film; Soft silicone dressing; Breast cancer
Funding
- Molnlycke Healthcare LTD
- University of Otago Research grant
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Purpose: Safetac-based soft silicone dressings used in a management setting decrease the severity of radiation-induced acute skin reactions but do not affect moist desquamation rates. Here we investigate the prophylactic use of another Safetac product, Mepitel Film, on moist desquamation rates. Material and methods: A total of 80 breast cancer patients receiving radiation therapy were recruited between October 2012 and April 2013; 78 participants contributed data for analysis. Lateral and medial halves of the skin areas to be irradiated were randomised to Mepitel Film or aqueous cream; skin dose was measured using thermoluminescent dosimeters; skin reaction severity was assessed using RISRAS and RTOG scales. Results: Overall skin reaction severity was reduced by 92% (p < 0.0001) in favour of Mepitel Film (RISRAS). All patients developed some form of reaction in cream-treated skin which progressed to moist desquamation in 26% of patients (RTOG grades I: 28%; IIA: 46%; IIB: 18%; III: 8%). Only 44% of patients had a skin reaction under the Film, which did not progress to moist desquamation in any of the patients (RTOG grades I: 36%; IIA: 8%). Conclusions: Mepitel Film completely prevented moist desquamation and reduced skin reaction severity by 92% when used prophylactically in our cohort. (C) 2014 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 110 (2014) 137-143
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