Journal
RADIOTHERAPY AND ONCOLOGY
Volume 108, Issue 2, Pages 293-298Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2013.07.006
Keywords
Breast radiotherapy; NTCP; Breast fibrosis; Breast conserving treatment; Late complications
Funding
- Efficacy and Mechanism Evaluation programme, Medical Research Council, UK [09/150/16]
- Cambridge National Institute of Health Research Biomedical Research Centre
- Fonds Cancer (FOCA) from Belgium
- Cancer Research UK [10588] Funding Source: researchfish
- Medical Research Council [G9600656, MC_PC_11001] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0510-10026] Funding Source: researchfish
- MRC [G9600656, MC_PC_11001] Funding Source: UKRI
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Introduction: The dose-volume effect of radiation therapy on breast tissue is poorly understood. We estimate NTCP parameters for breast fibrosis after external beam radiotherapy. Materials and methods: We pooled individual patient data of 5856 patients from 2 trials including whole breast irradiation followed with or without a boost. A two-compartment dose volume histogram model was used with boost volume as the first compartment and the remaining breast volume as second compartment. Results from START-pilot trial (n = 1410) were used to test the predicted models. Results: 26.8% patients in the Cambridge trial (5 years) and 20.7% patients in the EORTC trial (10 years) developed moderate-severe breast fibrosis. The best fit NTCP parameters were BEUD3(50) = 136.4 Gy, gamma 50 = 0.9 and n = 0.011 for the Niemierko model and BEUD3(50) = 132 Gy, m = 0.35 and n = 0.012 for the Lyman Kutcher Burman model. The observed rates of fibrosis in the START-pilot trial agreed well with the predicted rates. Conclusions: This large multi-centre pooled study suggests that the effect of volume parameter is small and the maximum RT dose is the most important parameter to influence breast fibrosis. A small value of volume parameter 'n' does not fit with the hypothesis that breast tissue is a parallel organ. However, this may reflect limitations in our current scoring system of fibrosis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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