Journal
RADIOTHERAPY AND ONCOLOGY
Volume 109, Issue 2, Pages 323-329Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2013.06.044
Keywords
Head and neck cancer; Radiotherapy; Elective nodes; Dose reduction
Funding
- Vlaamse Liga tegen Kanker (Flemish league against cancer)
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Background and purpose: A randomized trial was initiated to investigate whether a reduction of the dose to the elective nodal sites and the swallowing apparatus delivered by IMRT would result in a reduction of acute and late side effects without compromising tumor control. The aim of this paper is to report on dosimetrical analysis and acute toxicity. Materials & methods: Two-hundred patients were randomized. In the standard arm, elective nodal volumes (PTVelect) were irradiated up to an equivalent dose of 50 Gy. In the experimental arm an equivalent dose of 40 Gy was prescribed to the PTVelect. The dose to the swallowing apparatus was kept as low as possible without compromising therapeutic PTV (PTVther) coverage. Results: No significant difference was seen between both arms concerning PTVther coverage. The median D-95 of the PTVelect was significantly lower in the experimental arm (39.5 vs 49.8 Gy; p < 0.001). Concerning the organs at risk, the dose to swallowing structures and spinal cord was significantly reduced. There was no significant difference in acute toxicity. Three months after radiotherapy there was significantly less grade >= 3 dysphagia in the experimental arm (2% vs 11%; p = 0.03). With a median follow-up of 6 months no significant differences were observed in locoregional control, disease free survival or overall survival. Conclusions: Using IMRT we were able to significantly reduce the dose to the PTVelect and several organs at risk without compromising PTVther coverage. This resulted in a significant reduction of severe dysphagia 3 months after radiotherapy. Further follow-up is necessary to investigate whether these observations translate into a benefit on late treatment related dysphagia without affecting treatment outcome. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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