Journal
RADIATION PROTECTION DOSIMETRY
Volume 160, Issue 1-3, Pages 100-103Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rpd/ncu059
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Funding
- Scientific Grant Agency of the Ministry of Education of the Slovak republic (VEGA projects) [1/0678/09, 1/0143/14]
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Lung cancer is the leading cause of cancer death in both men and women. Smoking causes 80-90 % of cases of lung cancer. In this study, an attempt was made to assess the impact of cigarette smoking on the risk of lung cancer by the so-called threshold-specific energy model. This model allows to analyse the biological effects of radon daughter products on the lung tissue, and is based on the assumption that the biological effect (i.e. cell inactivation) will manifest itself after the threshold-specific energy z(0) deposited in the sensitive volume of the cell is exceeded. Cigarette smoking causes, among others, an increase in the synthesis of the survivin protein that protects cells from apoptosis and thereby reduces their radiosensitivity. Based on these facts, an attempt was made to estimate the shape of the curves describing the increase in the oncological effect of radiation as a function of daily cigarette consumption.
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