Journal
DRUG DESIGN DEVELOPMENT AND THERAPY
Volume 9, Issue -, Pages 2735-2744Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DDDT.S80902
Keywords
traditional Chinese medicine; antitumor effects; apoptotic pathway
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Funding
- Natural Science Foundation of China [81072065, 81273550, 81302906]
- Innovative Drug Development Project of China [2014ZX09102043]
- Beijing Natural Science Foundation [7144190]
- Shandong Provincial Natural Science Foundation [ZR2014HQ031]
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Defects in apoptosis are common phenomena in many types of cancer and are also a critical step in tumorigenesis. Targeting the apoptotic pathway has been considered an intriguing strategy for cancer therapy. Traditional Chinese medicine (TCM) has been used in the People's Republic of China for thousands of years, and many of the medicines have been confirmed to be effective in the treatment of a number of tumors. With increasing cancer rates worldwide, the antitumor effects of TCMs have attracted more and more attention globally. Many of the TCMs have been shown to have antitumor activity through multiple targets, and apoptosis pathway-related targets have been extensively studied and defined to be promising. This review focuses on several antitumor TCMs, especially those with clinical efficacy, based on their effects on the apoptotic signaling pathway. The problems with and prospects of development of TCMs as anticancer agents are also presented.
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