Journal
RADIATION PROTECTION DOSIMETRY
Volume 133, Issue 1, Pages 2-11Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rpd/ncp003
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- International Associated Laboratory CNRS-KEK-CEA France-Japan Particle Physics Laboratory (FJPPL)
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Microbeam facilities provide a unique opportunity to investigate the effects of ionising radiation on living biological cells with a precise control of the delivered dose. This paper describes dosimetry calculations performed at the single-cell level in the microbeam irradiation facility available at the Centre d'Etudes Nucleaires de Bordeaux-Gradignan in France, using the object-oriented Geant4 Monte Carlo simulation toolkit. The cell geometry model is based on high-resolution three-dimensional voxelised phantoms of a human keratinocyte (HaCaT) cell line. Such phantoms are built from confocal microscopy imaging and from ion beam chemical elemental analysis. Results are presented for single-cell irradiation with 3 MeV incident alpha particles.
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