Journal
RADIATION PHYSICS AND CHEMISTRY
Volume 92, Issue -, Pages 93-98Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.radphyschem.2013.06.007
Keywords
Pulse radiolysis; Methyl substituted salicylates; Hydroxyl radicals; Hydrated electron; Irradiation; Transient absorption spectra
Funding
- Office of Basic Energy Sciences, U.S. Department of Energy
- National Science Foundation [CBET-1034555]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1034555] Funding Source: National Science Foundation
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Salicylic acid and its derivatives are components of many medications and moieties found in numerous pharmaceutical compounds. They have been used as models for various pharmaceutical compounds in pharmacological studies, for the treatment of pharmaceuticals and personal care products (PPCPs), and, reactions with natural organic matter (NOM). In this study, the radiation chemistry of benzoic acid, salicylic acid and four methyl substituted salicylic acids (MSA) is reported. The absolute bimolecular reaction rate constants for hydroxyl radical reaction with benzoic and salicylic acids as well as 3-methyl-, 4-methyl-, 5-methyl-, and 6-methyl-salicylic acid were determined (5.86 +/- 0.54) x 10(9), (1.07 +/- 0.07) x 10(10), (7.48 +/- 0.17) x 10(9), (731 +/- 0.29) x 10(9), (5.47 +/- 025) x 10(9), (6.94 +/- 0.10) x 10(9) (M-1 s(-1)), respectively. The hydrated electron reaction rate constants were measured (3.02 +/- 0.10) x 10(9), (8.98 +/- 027) x 10(9), (5.39 +/- 0.21) x 10(9), (433 +/- 0.17) x 10(9), (4.72 +/- 0.15) x 10(9), (1.42 +/- 0.02) x 10(9) (M-1 s(-1)), respectively. The transient absorption spectra for the six model compounds were examined and their role as model compounds for the radiation chemistry of pharmaceuticals investigated. (C) 2013 Elsevier Ltd. All rights reserved.
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