Journal
RADIATION PHYSICS AND CHEMISTRY
Volume 78, Issue 3, Pages 177-183Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.radphyschem.2008.11.003
Keywords
Gold nanoparticles; Human centrin 2; Radio-sensitization; X-rays
Funding
- Curie Institute (PIC Physico-Chimie du vivant)
- Canadian Institutes of Health Research (CIHR)
- Centre National de la Recherche Scientifique (CNRS)
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in the war against cancer, radiotherapy is a prominent tool but counterbalanced by the fact that it also induces damages in healthy tissues. Nanotechnologies could open a new possibility to decrease these side effects. In particular, gold nanoparticles (GNPs) could be used as radio-sensitizers. As the role of proteins in the processes leading to cell death cannot be neglected, their radio-sensitization by GNPs is of great interest. This is particularly true in the case of the human centrin 2 protein, which has been proposed to be involved in DNA repair processes. To investigate this effect, we quantified for the first time the degradation of this protein in a gold colloidal solution when submitted to X-rays. We showed that the X-ray-induced degradation of the human centrin 2 protein is enhanced 1.5-fold in the presence of GNPs, even though no covalent bond exists between protein and GNPs. Among the conditions tested, the maximum enhancement was found with the higher GNP:protein ratio of 2 x 10(-4) and with the higher X-ray energy of 49 keV. (c) 2008 Elsevier Ltd. All rights reserved.
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