Journal
DIABETOLOGY & METABOLIC SYNDROME
Volume 7, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s13098-015-0015-6
Keywords
GLUT4; Statin; Insulin resistance; Obesity; Inflammation; Subcutaneous adipose tissue
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Funding
- FAPESP (Sao Paulo State Foundation for Research) [2012/04831-1, 2013/18841-1, 2014/10007-5]
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Background: Decreased expression of glucose transporter protein GLUT4, encoded by the solute carrier 2A4 (Slc2a4) gene, is involved in obesity-induced insulin resistance. Local tissue inflammation, by nuclear factor-kappa B (NF kappa B)-mediated pathway, has been related to Slc2a4 repression; a mechanism that could be modulated by statins. Using a model of obesity with insulin resistance, this study investigated whether (1) inflammatory markers and Slc2a4 expression are altered; (2) atorvastatin has beneficial effects on inflammation and Slc2a4 expression; and (3) inhibitor of NF kappa B (IKK)/NF kappa B pathway is involved in subcutaneous adipose tissue (SAT). Findings: Obese mice showed insulin resistance, decreased expression of Slc2a4 mRNA (66%, P < 0.01) and GLUT4 protein (30%, P < 0.05), and increased expression of interleukin 6 (Il6) mRNA (44%, P < 0.05) in SAT. Obese mice treated with atorvastatin had enhanced in vivo insulin sensitivity, besides increased Slc2a4/GLUT4 expression and reduced Il6 expression in SAT. No alterations of tumor necrosis factor-alpha, interleukin 1 beta and adiponectin expression or IKK alpha/beta activity in SAT of obese mice or obese mice treated with atorvastatin were observed. Conclusions: Atorvastatin has beneficial effect upon glycemic homeostasis, which may be related to its positive impact on Il6 and Slc2a4/GLUT4 expression in SAT.
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