Boron thin films and CR-39 detectors in BNCT: A method to measure the 10B(n,α)7Li reaction rate

The working principle of the Boron Neutron Capture Therapy (BNCT) is the selective delivery of a greater amount of boron to the tumor cells than to the healthy ones, followed by the neutron irradiation that will induce the emission of alpha-particles and recoil Li-7 nuclei through the B-10(n,alpha)Li-7 reaction. The objective of this work is to present a setup composed of a boron thin film coupled with CR-39. Alpha and Li-7 particle coming from the boron films are used to quantify neutron boron reaction and are detected by CR-39. The nuclei compounding of this detector, H, C and O, will undergo fast neutrons reactions, which will be detected in the CR-39 itself. In this way, the B-10(n,alpha)Li-7 reaction and the contribution of fast neutrons to the flux can be determined at the same time. These measurements are essential for treatment planning as well as for studies of the biodistribution of B-10-carrier drugs and tissue microdosimetry. The boron films were deposited on stainless steel substrates through the sputtering technique and irradiated with thermal neutrons at the reactor lEA-R1 located at IPEN, Sao Paulo/SP, Brazil. Here we show the first results on the characterization of these thin films and calibration of the proposed setup. (c) 2012 Elsevier Ltd. All rights reserved.