Journal
QUIMICA NOVA
Volume 35, Issue 11, Pages 2245-2248Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0100-40422012001100029
Keywords
Schinus terebinthifolius; phenolic derivatives; cytotoxic activity
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ISOLATION AND EVALUATION OF CYTOTOXIC POTENTIAL OF PHENOLIC DERIVATIVES FROM Schinus terebinthifolius Raddi (Anacardiaceae). The EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H2O and hexane, CH2Cl2, and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1), methyl (2) and ethyl (3) gallates, trans-catechin (4), quercitrin (5), and afzelin (6), being the first occurrence of 1, 4 and 6 in S. terebinthifolius. In vitro cytotoxic evaluation of 1 - 6 indicated that gallic acid (1) displayed higher activity than ethyl gallate (3) against HL-60 and HeLa cells, while compounds 2, 4 - 6 were inactive.
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