PHOTOCHEMICAL CHARACTERISTICS OF DICLOFENAC AND ITS PHOTODEGRADATION OF INCLUSION COMPLEXES WITH β-CYCLODEXTRINS

Diclofenac is one of most frequently detected compounds in the water cycle. In this work, the effect of initial concentration, liquid inclusion complexes with beta-Cyclodextrins (beta-CDs) on the photodegradation of diclofenac were studied. Six phototransformation products were detected by HPLC chromatograms. UV-absorption spectra of diclofenac and phototransformation products were determined. One of the phototransformation products was identified. The degradation followed pseudo-first-order kinetics. The experiment showed that irradiation of diclofenac in the presence of beta-CDs increase photodegradation rate and determined the optimal molar ratio of diclofenac to beta-CDs as 1:2. The reduced photohaemolytic activity of diclofenac in the presence of beta-CDs may be attributed to the sequestering and stabilizing of the radical intermediates and /or photoproducts by complexation.