Journal
QUIMICA NOVA
Volume 33, Issue 3, Pages 667-679Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0100-40422010000300035
Keywords
microbial natural products; drug discovery; antibiotics
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ANTIBIOTICS: THERAPEUTIC IMPORTANCE AND PERSPECTIVES FOR THE DISCOVERY AND DEVELOPMENT OF NEW AGENTS. There is a continuous need for antibiotics, mainly with new mechanisms of action, since infectious diseases represent the second major cause of death in the world and bacteria resistance levels are high. This review describes the contribution of microbial natural products for the development of the major antibiotic classes, the mechanisms of action of current antibiotics. some modern approaches involving genetic tools for the discovery and development of new antibiotics front microbial products and antibiotics in clinical trials.
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