EVALUATION OF ANTI-Mycobacterium tuberculosis ACTIVITY OF Campomanesia adamantium (MYRTACEAE)

The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 mu g/mL) and their fractions (MIC values ranging from 39 to above 250 mu g/mL). The better MIC result of 39 mu g/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 mu g/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 mu g/mL, demonstrating a synergism between them.