Journal
CURRENT PSYCHIATRY REPORTS
Volume 17, Issue 12, Pages -Publisher
SPRINGER
DOI: 10.1007/s11920-015-0637-2
Keywords
Circadian rhythm; Psychiatric disorders; Metabolic syndrome; Depression; Reward; Obesity
Categories
Funding
- Veterans Affairs Merit Award [1I01BX001146]
- NARSAD
Ask authors/readers for more resources
Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available