Glutathione and related enzymes: Biological roles and importance in pathological processes

Glutathione (GSH) and related enzymes are pivoted for the normal functioning of several important biological processes. In this review we discuss the biosynthesis and the catalytic cycles of glutathione as well as the major GSH-related enzymes. We also present how glutathione and enzymes are involved in cancer and the chromatographic and non-chromatographic methods used to analyze glutathione and/or its derivatives.