Journal
QUIMICA NOVA
Volume 31, Issue 5, Pages 1099-1103Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0100-40422008000500030
Keywords
marine-derived fungi; screening; Beauveria felina
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Funding
- FAPESP
- NIH-NCI NCDDG
- CAPES
- CNPq
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Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and H-1 NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.
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