Journal
QUARTERLY REVIEWS OF BIOPHYSICS
Volume 45, Issue 2, Pages 209-255Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033583512000042
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Funding
- Ministerium fur Wissenschaft, Innovation, Forschung und Technologie des Landes Nordrhein-Westfalen
- National Science Foundation [CBET-0930074]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0930074] Funding Source: National Science Foundation
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The ability of metal surfaces and nanostructures to localize and enhance optical fields is the primary reason for their application in biosensing and imaging. Local field enhancement boosts the signal-to-noise ratio in measurements and provides the possibility of imaging with resolutions significantly better than the diffraction limit. In fluorescence imaging, local field enhancement leads to improved brightness of molecular emission and to higher detection sensitivity and better discrimination. We review the principles of plasmonic fluorescence enhancement and discuss applications ranging from biosensing to bioimaging.
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