Journal
CLEFT PALATE-CRANIOFACIAL JOURNAL
Volume 52, Issue 3, Pages 336-340Publisher
ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS
DOI: 10.1597/13-260
Keywords
beta-TCP; bone grafting; bone regeneration; bone substitute; cleft lip and palate (CLP)
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Objectives: Can a synthetic bone substitute be used to repair the alveolar cleft to bypass donor site morbidity as well as to shorten the operating time? In earlier experimental studies, micro-structured beta-tricalcium phosphate (beta-TCP) provided similar bone healing when compared with grafting with iliac crest bone. This justifies the clinical evaluation of this bone substitute in the human alveolar cleft situation. Design: Prospective clinical study. Setting: University clinic. Participants: Seven patients, all with unilateral alveolar cleft, were randomly included for alveolar cleft repair with beta-TCP in 2010 and 2011. Main Outcome Measures: In all patients, the alveolar cleft was repaired by micro-structured beta-TCP grafting. Our assessments were distilled from cone beam computed tomography scans taken preoperatively, 1 week postoperatively, and 6 months postoperatively. A volumetric outcome could be realized. Results: Six months after the operative grafting of micro-structured beta-TCP into the alveolar cleft, the bone volume thus acquired was satisfactory. We found an average bone volume percentage of 73% +/- 6% compared with the original cleft volume. Conclusions: Previous experimental and clinical studies and the initial findings of this pilot study now elucidate a path toward the clinical use of micro-structured beta-TCP bone substitute for cleft.
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