Journal
CELL ADHESION & MIGRATION
Volume 9, Issue 5, Pages 380-383Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2015.1019997
Keywords
cell traction; chemotaxis; collective cell migration; contact inhibition of locomotion; mesenchymal cell migration; morphogenesis; neural crest; N-Cadherin; placodes; Rac1
Categories
Funding
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Medical Research Council [MR/M010465/1] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- BBSRC [BB/M008517/1] Funding Source: UKRI
- MRC [MR/M010465/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M008517/1] Funding Source: researchfish
- Medical Research Council [MR/M010465/1] Funding Source: researchfish
Ask authors/readers for more resources
Directional collective cell migration plays an important role in development, physiology, and disease. An increasing number of studies revealed key aspects of how cells coordinate their movement through distances surpassing several cell diameters. While physical modeling and measurements of forces during collective cell movements helped to reveal key mechanisms, most of these studies focus on tightly connected epithelial cultures. Less is known about collective migration of mesenchymal cells. A typical example of such behavior is the migration of the neural crest cells, which migrate large distances as a group. A recent study revealed that this persistent migration is aided by the interaction between the neural crest and the neighboring placode cells, whereby neural crest chase the placodes via chemotaxis, but upon contact both populations undergo contact inhibition of locomotion and a rapid reorganization of cellular traction. The resulting asymmetric traction field of the placodes forces them to run away from the chasers. We argue that this chase and run interaction may not be specific only to the neural crest system, but could serve as the underlying mechanism for several morphogenetic processes involving collective cell migration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available