Journal
CELL ADHESION & MIGRATION
Volume 9, Issue 3, Pages 167-174Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2015.1027478
Keywords
adherens junction; -catenin; -catenin; differentiation; N-cadherin; proliferation; wnt; VZ; ventricular zone; SNP; short neural precursor; CBD; catenin binding domain; JMD; juxtamembrane domain; PI3K; phosphatidylinositol 3-kinase; PTEN; phosphatase and tensin homolog; GSK3; glycogen synthase kinase 3; PCP; planar cell polarity; SHH; sonic hedgehog; Hh; Hedgehog; CK1; Casein kinase 1; APC; Adenomatous polyposis coli
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The disproportional enlargement of the neocortex through evolution has been instrumental in the success of vertebrates, in particular mammals. The neocortex is a multilayered sheet of neurons generated from a simple proliferative neuroepithelium through a myriad of mechanisms with substantial evolutionary conservation. This developing neuroepithelium is populated by progenitors that can generate additional progenitors as well as post-mitotic neurons. Subtle alterations in the production of progenitors vs. differentiated cells during development can result in dramatic differences in neocortical size. This review article will examine how cadherin adhesion proteins, in particular -catenin and N-cadherin, function in regulating the neural progenitor microenvironment, cell proliferation, and differentiation in cortical development.
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