Journal
CELL ADHESION & MIGRATION
Volume 9, Issue 4, Pages 308-316Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2015.1005469
Keywords
cell culture; cell proliferation; collagen; extracellular matrix; fibroblasts; fibronectin; integrins; metalloproteinases; myofibroblasts; substrate stiffness; AP-1; activator protein 1; ECM; extracellular matrix; ERK; extracellular signal-regulated kinase; FAK; focal adhesion kinase; GT; granulation tissue; HSC; hepatic stellate cells; JNK; c-Jun N-terminal kinase; MFB; myofibroblasts; MKL1; megakaryoblastic leukemia 1; MMP; metalloproteinases; NF-B; nuclear factor kappa B; PI3K; Akt; phosphatidylinositide 3-kinase; Ak strain transforming; PEG; polyethylene glycol; -SMA; -smooth muscle actin; 3D; 3-dimensional; TGF-1; transforming growth factor 1; TIMP; tissue inhibitor of metalloproteinases; TNF-; tumor necrosis factor
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Type I collagen is a fibrillar protein, a member of a large family of collagen proteins. It is present in most body tissues, usually in combination with other collagens and other components of extracellular matrix. Its synthesis is increased in various pathological situations, in healing wounds, in fibrotic tissues and in many tumors. After extraction from collagen-rich tissues it is widely used in studies of cell behavior, especially those of fibroblasts and myofibroblasts. Cells cultured in a classical way, on planar plastic dishes, lack the third dimension that is characteristic of body tissues. Collagen I forms gel at neutral pH and may become a basis of a 3D matrix that better mimics conditions in tissue than plastic dishes.
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