Journal
CELL ADHESION & MIGRATION
Volume 9, Issue 5, Pages 392-393Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2015.1042197
Keywords
cancer progression; E5; E6/E7; gene cooperation; high-risk HPV
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Funding
- Canadian Institutes of Health Research Funding Source: Medline
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It is estimated that 10-20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, the role of onco-viruses in cancer progression to a metastatic form is of particular interest. Recent studies reported that E5 and E6/E7 onco-proteins of high-risk HPVs could enhance cancer progression via the initiation of the epithelial-mesenchymal transition (EMT) event. Herein, we discuss the association between E5 as well as E6/E7 of high-risk HPV and cancer progression.
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