Journal
CATALYSIS SCIENCE & TECHNOLOGY
Volume 5, Issue 9, Pages 4474-4480Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cy00907c
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- State of Mecklenburg-Vorpommern
- Bundesministerium fur Bildung und Forschung (BMBF)
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Quinazolinones are of interest in the fields of pharmaceuticals and medicinal chemistry. The application of palladium on activated charcoal (Pd/C) as a heterogeneous catalyst was investigated for the carbonylation of 2-iodoanilines with trimethyl orthoformate and amines via a multicomponent reaction approach, which provided excellent yields of 4(3H)-quinazolinones. It avoids the use of expensive phosphine ligands with an additional advantage of catalyst recovery. Furthermore, >5 new quinazolinone scaffolds containing the trifluoroethyl group were introduced by this procedure; gram scale experiments were successfully performed as well.
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