Journal
QUANTUM ELECTRONICS
Volume 38, Issue 6, Pages 551-556Publisher
TURPION LTD
DOI: 10.1070/QE2008v038n06ABEH013850
Keywords
glucose; permeability; noninvasive method; in-depth resolution; optical coherence tomography
Funding
- W. Coulter Foundation and Office of Naval Research (KVL)
- Federal Agency of Education of Russian Federation [1.4.06, RNP.2.1.1.4473]
- RFBR [N06-02-16740]
- Program of Innovative Universities
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Functional imaging, monitoring and quantitative description of glucose diffusion in epithelial and underlying stromal tissues in vivo and controlling of the optical properties of tissues are extremely important for many biomedical applications including the development of noninvasive or minimally invasive glucose sensors as well as for therapy and diagnostics of various diseases, such as cancer, diabetic retinopathy, and glaucoma. Recent progress in the development of a noninvasive molecular diffusion biosensor based on optical coherence tomography (OCT) is described. The diffusion of glucose was studied in several epithelial tissues both in vitro and in vivo. Because OCT provides depth-resolved imaging of tissues with high in-depth resolution, the glucose diffusion is described not only as a function of time but also as a function of depth.
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