Journal
QUALITY OF LIFE RESEARCH
Volume 23, Issue 1, Pages 1-4Publisher
SPRINGER
DOI: 10.1007/s11136-013-0443-4
Keywords
Minimally important difference; Clinical significance; Quality of life; Patient-reported outcomes; Regression to the mean
Categories
Funding
- NIA [P30-AG021684]
- NIMHD [P20MD000182]
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Minimal important differences (MIDs) for patient-reported outcomes (PROs) are often estimated by selecting a clinical variable to serve as an anchor. Then, differences in the clinical anchor regarded as clinically meaningful or important can be used to estimate the corresponding value of the PRO. Although these MID values are sometimes estimated by regression techniques, we show that this is a biased procedure and should not be used; alternative methods are proposed.
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