Journal
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
Volume 107, Issue 10, Pages 789-792Publisher
OXFORD UNIV PRESS
DOI: 10.1093/qjmed/hcu005
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Funding
- National Natural Science Foundation of China [81270139]
- Key Project of Science and Technology of Shanghai [12JC1408900]
- Chinese Academy of Sciences [Y316P21209, Y114P11209]
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In this review, we first analyzed the current status of cholinergic anti-inflammatory pathway and then put forward a novel regulatory machinery-pulmonary parasympathetic inflammatory reflex, which is composed by lung vagal sensors at afferent arm, alpha 7 nAChR (alpha 7 nicotinic acetylcholine receptors)-expressing cells at efferent arm and the brain information integrating center. This modulatory circuit might loop the lungs, immune and nervous systems and play a very important role in regulating lung infection, inflammation and immunity through the neural innervations and signals when the lungs encounter pathogenic challenges.
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