Journal
CANCER DISCOVERY
Volume 5, Issue 7, Pages 697-700Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-15-0609
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Funding
- NCI NIH HHS [R01 CA158383, F32 CA189629, T32 CA009054] Funding Source: Medline
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Enzymes (PI3K and PTEN) controlling cellular levels of 3-phosphorylated phosphoinositides are known as important drivers or suppressors of tumorigenesis in various cancers. In this issue of Cancer Discovery, Kofuji and colleagues and Chew and colleagues identify the lipid phosphatase INPP4B as a context-specific tumor suppressor that controls phosphoinositide levels and AKT2 activation in PTEN-deficient cells. (C) 2015 AACR.
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