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AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Paracrine stimulation of vascular smooth muscle proliferation by diadenosine polyphosphates released from proximal tubule epithelial cells
V. Jankowski et al.
KIDNEY INTERNATIONAL (2007)
aPKC-PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion
Shobha Gopalakrishnan et al.
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Increased expression of the pro-apoptotic ATP-sensitive P2X7 receptor in experimental and human glomerulonephritis
Clare M. Turner et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2007)
Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity
S. Klawitter et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
P2Y1 gene deficiency protects from renal disease progression and capillary rarefaction during passive crescentic glomerulonevhritis
Bernd Hohenstein et al.
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Mediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine
H. Castrop
ACTA PHYSIOLOGICA (2007)
Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro
Clare M. Turner et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells
Zabeena P. Shaik et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Assessment of renal autoregulation
William A. Cupples et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Basolateral P2X(4)-like receptors regulate the extracellular ATP-stimulated epithelial Na+ channel activity in renal epithelia
Yanjun Zhang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
P-1, P-4-diadenosine tetraphosphate (Ap(4)A) inhibits proximal tubular reabsorption of sodium in rats
Anna Stiepanow-Trzeciak et al.
NEPHRON PHYSIOLOGY (2007)
Effects of ATP on rat renal haemodynamics and excretion: role of sodium intake, nitric oxide and cytochrome P450
L. Dobrowolski et al.
ACTA PHYSIOLOGICA (2007)
Extracellular adenosine triphosphate protects oxidative stress-induced increase of p21WAF1/Cip1 and P27Kip1 expression in primary cultured renal proximal tubule cells:: Role of PI3K and Akt signaling
Yun Jung Lee et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells
Selvi C. Jeyaraj et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)
Regional vascular responses to ATP and ATP analogues in the rabbit kidney in vivo:: roles for adenosine receptors and prostanoids
G. A. Eppel et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Transient activation and delayed inhibition of Na+, K+, Cl- cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms
Olga A. Akimova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Calcium wave of tubuloglomerular feedback
Janos Peti-Peterdi
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)
Intraluminal ATP concentrations in rat renal tubules
Renu M. Vekaria et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Adenosine receptor antagonism in acute tacrolimus toxicity
Gwenn E. McLaughlin et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2006)
Role of ATP in DNA synthesis of renal proximal tubule cells: involvement of calcium, MAPKs, and CDKs
Yun Jung Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)
Exogenous 5′-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats
T Takenaka et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)
Assessing the risk of infection and rejection in hispanic renal transplant recipients by means of an adenosine triphosphate release assay
R. Cadillo-Chavez et al.
TRANSPLANTATION PROCEEDINGS (2006)
Extracellular ATP stimulates NO production in rat thick ascending limb
G Silva et al.
HYPERTENSION (2006)
Immunolocalization of ectonucleotidases along the rat nephron
RM Vekaria et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium
S Locovei et al.
FEBS LETTERS (2006)
Localization of connexin 30 in the luminal membrane of cells in the distal nephron
F McCulloch et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
ATP stimulates Na+-glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells
YJ Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2005)
Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P2Y1 receptors, phospholipase A2 and protein kinase A
AO Akimova et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
Aldosterone acts via an ATP autocrine/paracrine system:: The Edelman ATP hypothesis revisited
J Gorelik et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Blood pressure-dependent inhibition of renin secretion requires A1 adenosine receptors
F Schweda et al.
HYPERTENSION (2005)
Effect of adenosine triphosphate on phosphate uptake in renal proximal tubule cells: Involvement of PKC and p38 MAPK
YJ Lee et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
P2Y2 receptor-mediated release of prostaglandin E2 by IMCD is altered in hydrated and dehydrated rats:: relevance to AVP-independent regulation of IMCD function
RJ Sun et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
Regulatory interdependence of cloned epithelial Na+ channels and P2X receptors
SS Wildman et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)
Expression of polycystin-1 enhances endoplasmic reticulum calcium uptake and decreases capacitative calcium entry in ATP-stimulated MDCK cells
KM Hooper et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
Mechanisms of adenosine-induced renal vasodilatation in hypertensive patients
TKA Wierema et al.
JOURNAL OF HYPERTENSION (2005)
Adenosine inhibits PDGF-induced growth of human glomerular mesangial cells via A2B receptors
RK Dubey et al.
HYPERTENSION (2005)
Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids
EL Liclican et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
The ATP levels in kidneys and blood are mainly decreased by acute ingestion of tullidora (Karwinskia humboldtiana)
F Jaramillo-Juárez et al.
TOXICON (2005)
In vivo stimulation of apical P2 receptors in collecting ducts: evidence for inhibition of sodium reabsorption
DG Shirley et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
P2Y2 receptor mRNA and protein expression is altered in inner medullas of hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function
BK Kishore et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
Evidence for the existence of P2Y12,4 receptor subtypes in HEK-293 cells:: reactivation of P2Y1 receptors after repetitive agonist application
W Fischer et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2005)
Expression of NTPDase1 and NTPDase2 in murine kidney:: relevance to regulation of P2 receptor signaling
[Anonymous]
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
Overexpression of manganese superoxide dismutase protects against ATP depletion-mediated cell death of proximal tubule cells
DL Cruthirds et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
Effects of diadenosine polyphosphates on glomerular volume
M Szczepanska-Konkel et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
IP Chessell et al.
PAIN (2005)
Adenosine induces ATP release via an inositol 1,4,5-trisphosphate signaling pathway in MDCK cells
K Migita et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Purinergic modulation of mesangial extracellular matrix production: Role in diabetic and other glomerular diseases
A Solini et al.
KIDNEY INTERNATIONAL (2005)
Cyclosporin and tacrolimus increase plasma levels of adenosine in kidney transplanted patients
PL Capecchi et al.
TRANSPLANT INTERNATIONAL (2005)
ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling
JH Hu et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Stimulation of the proximal tubule Na+-ATPase activity by adenosine A(2A) receptor
M Wengert et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)
Transepithelial pressure pulses induce nucleotide release in polarized MDCK cells
HA Praetorius et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
Gene expression of adenosine receptors along the nephron
H Vitzthum et al.
KIDNEY INTERNATIONAL (2004)
Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells
L Guerra et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
The P2X7 ATP receptor modulates renal cyst development in vitro
KA Hillman et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Inhibition of apoptosis by Zn2+ in renal tubular cells following ATP depletion
QQ Wei et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)
Extracellular ATP-induced calcium signaling in mIMCD-3 cells requires both P2X and P2Y purinoceptors
SL Xia et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)
Luminal flow induces eNOS activation and translocation in the rat thick ascending limb
PA Ortiz et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)
Renal autoregulation in P2X1 knockout mice
EW Inscho et al.
ACTA PHYSIOLOGICA SCANDINAVICA (2004)
Modeling of basolateral ATP release induced by hypotonic treatment in A6 cells
M Gheorghiu et al.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2004)
Glomerular expression of the ATP-sensitive P2X7 receptor in diabetic and hypertensive rat models
O Vonend et al.
KIDNEY INTERNATIONAL (2004)
Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells
CY Xin et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
Role of interstitial ATP and adenosine in the regulation of renal hemodynamics and microvascular function
A Nishiyama et al.
HYPERTENSION RESEARCH (2004)
Macula densa basolateral ATP release is regulated by luminal [NaCl] and dietary salt intake
P Komlosi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)
Experimental hypothyroidism modifies specific binding of A1 and A2A analogues to adenosine receptors in the rat kidney
M Franco et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
Altered ATP-sensitive P2 receptor subtype expression in the Han : SPRD cy/+ rat, a model of autosomal dominant polycystic kidney disease
CM Turner et al.
CELLS TISSUES ORGANS (2004)
Romancing the macula densa at UAB
LG Navar et al.
KIDNEY INTERNATIONAL (2004)
Inhibition of bicarbonate reabsorption in the rat proximal tubule by activation of luminal P2Y1 receptors
MA Bailey
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)
A panoramic view of gene expression in the human kidney
D Chabardès-Garonne et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Adenosine A1 receptor antagonists and the kidney
PS Modlinger et al.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2003)
An ecdysone and tetracycline dual regulatory expression system for studies on Rac1 small GTPase-mediated signaling
JF Lai et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)
ATP-dependent mechanism for coordination of intercellular Ca2+ signaling and renin secretion in rat juxtaglomerular cells
J Yao et al.
CIRCULATION RESEARCH (2003)
P2Y-Receptors stimulating the proliferation of human mesangial cells through the MAPK42/44 pathway
O Vonend et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes
SM Joseph et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Third-generation β-blockers stimulate nitric oxide release from endothelial cells through ATP efflux -: A novel mechanism for antihypertensive action
L Kalinowski et al.
CIRCULATION (2003)
Expression of multiple P2Y receptors by MDCK-D1 cells:: P2Y1 receptor cloning and signaling
RJ Hughes et al.
DRUG DEVELOPMENT RESEARCH (2003)
P2X7 receptor-induced generation of reactive oxygen species in rat mesangial cells
H Harada et al.
DRUG DEVELOPMENT RESEARCH (2003)
Characterization of P2X3, P2Y1 and P2Y4 receptors in cultured HEK293-hP2X3 cells and their inhibition by ethanol and trichloroethanol
W Fischer et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Macula densa cell signaling involves ATP release through a maxi anion channel
PD Bell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Control of epithelial transport via luminal P2 receptors
J Leipziger
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)
A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure
HT Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)
Extended pharmacological profiles of rat P2Y(2) and rat P2Y(4) receptors and their sensitivity to extracellular H+ and Zn2+ ions
SS Wildman et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Paracrine factors in tubuloglomerular feedback: Adenosine, ATP, and nitric oxide
J Schnermann et al.
ANNUAL REVIEW OF PHYSIOLOGY (2003)
The pattern of distribution of selected ATP-sensitive P2 receptor subtypes in normal rat kidney: An immunohistological study
CM Turner et al.
CELLS TISSUES ORGANS (2003)
Basolateral and apical A1 adenosine receptors mediate sodium transport in cultured renal epithelial (A6) cells
LJ Macala et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2002)
Hypotonic treatment evokes biphasic ATP release across the basolateral membrane of cultured renal epithelia (A6)
D Jans et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)
Adenosine type 1 receptor antagonists in fluid retaining disorders
WJ Welch
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2002)
P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis
S Rost et al.
KIDNEY INTERNATIONAL (2002)
Effects of nitric oxide on P2Y receptor resensitization in spontaneously hypertensive rat mesangial cells
RS Liu et al.
JOURNAL OF HYPERTENSION (2002)
Treatment with an adenosine uptake inhibitor attenuates glomerulonephritis in mice
T Noji et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
Role of mesangial cells and gap junctions in tubuloglomerular feedback
YL Ren et al.
KIDNEY INTERNATIONAL (2002)
Uridine nucleotide-induced stimulation of gluconeogenesis in isolated rat proximal tubules
J Mo et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2002)
Extracellular adenine nucleotides regulate Na+/H+ exchanger NHE3 activity in A6-NHE3 transfectants by a cAMP/PKA-dependent mechanism
A Bagorda et al.
JOURNAL OF MEMBRANE BIOLOGY (2002)
Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response
JM Labasi et al.
JOURNAL OF IMMUNOLOGY (2002)
Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y2 purinoceptor in renal mesangial cells
A Huwiler et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Cisplatin up-regulates the adenosine A1 receptor in the rat kidney
SG Bhat et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
ATP release in human kidney cortex and its mitogenic effects in visceral glomerular epithelial cells
O Vonend et al.
KIDNEY INTERNATIONAL (2002)
Adenosine-induced apoptosis in glomerular mesangial cells
ZH Zhao et al.
KIDNEY INTERNATIONAL (2002)
Purinergic-induced ion current in monolayers of C7-MDCK cells: Role of basolateral and apical ion transporters
N Bourcier et al.
JOURNAL OF MEMBRANE BIOLOGY (2002)
Adenosine A1 receptor antagonists in the kidney:: effects in fluid-retaining disorders
WJ Welch
CURRENT OPINION IN PHARMACOLOGY (2002)
Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys
EM Schwiebert et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2002)
Basolateral, but not apical, ATP inhibits vasopressin action in rat inner medullary collecting duct
RM Edwards
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
P2Y11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D1 cells -: A mechanism for nucleotide-mediated autocrine-paracrine regulation
B Torres et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Role of gap junctions in fluid secretion of lacrimal glands
B Walcott et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)
Purinergic signaling and vascular cell proliferation and death
G Burnstock
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)
Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice
R Brown et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2001)
NO decreases thick ascending limb chloride absorption by reducing Na+-K+-2Cl- cotransporter activity
PA Ortiz et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2001)
P2Y2 receptor-mediated inhibition of amiloride-sensitive short circuit current in M-1 mouse cortical collecting duct cells
J Thomas et al.
JOURNAL OF MEMBRANE BIOLOGY (2001)
Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1 receptors
DQ Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
P2X receptor immunoreactivity in different arteries from the femoral, pulmonary, cerebral, coronary and renal circulations
CJ Lewis et al.
JOURNAL OF VASCULAR RESEARCH (2001)
ATP release mechanisms, ATP receptors and purinergic signalling along the nephron
ER Schwiebert
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2001)
P2Y receptors of MDCK cells: Epithelial cell regulation by extracellular nucleotides
PA Insel et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2001)
Regulation of an outwardly rectifying chloride conductance in renal epithelial cells by external and internal calcium
GS Stewart et al.
JOURNAL OF MEMBRANE BIOLOGY (2001)
Renal interstitial ATP responses to changes in arterial pressure during alterations in tubuloglomerular feedback activity
A Nishiyama et al.
HYPERTENSION (2001)
Immunolocalisation of adenosine A1 receptors in the rat kidney
JA Smith et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Sympathetic overactivity and arterial hypertension in renal failure
SR Orth et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2001)
Potentiation of cytokine induction of group IIA phospholipase A(2) in rat mesangial cells by ATP and adenosine via the A2A adenosine receptor
K Scholz-Pedretti et al.
BRITISH JOURNAL OF PHARMACOLOGY (2001)
Cyclic GMP-dependent relaxation of isolated rat renal glomeruli induced by extracellular ATP
M Jankowski et al.
JOURNAL OF PHYSIOLOGY-LONDON (2001)
Capacity for purinergic control of renin promoter via P2Y11 receptor and cAMP pathways
L van der Weyden et al.
HYPERTENSION (2000)
Axial distribution and characterization of basolateral P2Y receptors along the rat renal tubule
MA Bailey et al.
KIDNEY INTERNATIONAL (2000)
P2 receptors in the kidney
MA Bailey et al.
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM (2000)
Cellular release of and response to ATP as key determinants of the set-point of signal transduction pathways
RS Ostrom et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Growth hormones reverse desensitization of P2Y2 receptors in rat mesangial cells
AM Gutierrez et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Differential expression of renal adenosine A1 receptors induced by acute renal failure
JA Smith et al.
BIOCHEMICAL PHARMACOLOGY (2000)
ATP stimulates Cl- secretion and reduces amiloride-sensitive Na+ absorption in M-1 mouse cortical collecting duct cells
JE Cuffe et al.
JOURNAL OF PHYSIOLOGY-LONDON (2000)
Extracellular nucleotides activate the p38-stress-activated protein kinase cascade in glomerular mesangial cells
A Huwiler et al.
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