4.3 Article

P2X receptor antagonists for pain management: examination of binding and physicochemical properties

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Inhibition of Neuronal Voltage-Gated Sodium Channels by Brilliant Blue G

Sooyeon Jo et al.

MOLECULAR PHARMACOLOGY (2011)

Article Anesthesiology

P2X7 receptor-deficient mice are susceptible to bone cancer pain

Rikke Rie Hansen et al.

Article Chemistry, Medicinal

Synthesis and in vivo evaluation of 3-substituted gababutins

David C. Blakemore et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Chemistry, Medicinal

Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist

Christine E. Brotherton-Pleiss et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Pharmacology & Pharmacy

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

Joel R. Gever et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Review Chemistry, Medicinal

P2X purinergic receptor ligands: recently patented compounds

Hendra Gunosewoyo et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2010)

Review Neurosciences

The neural-glial purinergic receptor ensemble in chronic pain states

Michael F. Jarvis

TRENDS IN NEUROSCIENCES (2010)

Article Chemistry, Medicinal

Using the Golden Triangle to optimize clearance and oral absorption

Ted W. Johnson et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Article Pharmacology & Pharmacy

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors

Diana L. Donnelly-Roberts et al.

BRITISH JOURNAL OF PHARMACOLOGY (2009)

Review Biochemistry & Molecular Biology

Cellular and Molecular Mechanisms of Pain

Allan I. Basbaum et al.

Review Chemistry, Medicinal

Antagonists of the P2X7 Receptor. From Lead Identification to Drug Development

Simon D. Guile et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Neurosciences

Morphine Enhances Microglial Migration through Modulation of P2X4 Receptor Signaling

Ryan J. Horvath et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Multidisciplinary Sciences

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

Toshimitsu Kawate et al.

NATURE (2009)

Review Neurosciences

ATP-gated P2X cation-channels

Michael F. Jarvis et al.

NEUROPHARMACOLOGY (2009)

Review Biochemistry & Molecular Biology

The P2X7 receptor-pannexin connection to dye uptake and IL-1β release

Pablo Pelegrin et al.

PURINERGIC SIGNALLING (2009)

Article Chemistry, Medicinal

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D. Hughes et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

Review Biochemistry & Molecular Biology

Blood-brain barrier permeability considerations for CNS-targeted compound library design

Stephen A. Hitchcock

CURRENT OPINION IN CHEMICAL BIOLOGY (2008)

Review Pharmacology & Pharmacy

The P2X7 receptor as a therapeutic target

Romeo Romagnoli et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2008)

Article Neurosciences

Phosphoinositides Regulate P2X4 ATP-Gated Channels through Direct Interactions

Louis-Philippe Bernier et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Pharmacology & Pharmacy

Painful purinergic receptors

Diana Donnelly-Roberts et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

Article Biotechnology & Applied Microbiology

The influence of drug-like concepts on decision-making in medicinal chemistry

Paul D. Leeson et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

Article Biochemistry & Molecular Biology

Modification of neuropathic pain sensation through microglial ATP receptors

Kazuhide Inoue et al.

PURINERGIC SIGNALLING (2007)

Article Chemistry, Medicinal

From tyrosine to glycine:: Synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor

Romeo Romagnoli et al.

JOURNAL OF MEDICINAL CHEMISTRY (2007)

Article Neurosciences

P2x7-related modulation of pathological nociception in rats

S. McGaraughty et al.

NEUROSCIENCE (2007)

Review Physiology

Physiology and pathophysiology of purinergic neurotransmission

Geoffrey Burnstock

PHYSIOLOGICAL REVIEWS (2007)

Review Neurosciences

Timeline - Ideas about pain, a historical view

Edward R. Perl

NATURE REVIEWS NEUROSCIENCE (2007)

Review Multidisciplinary Sciences

P2X receptors as cell-surface ATP sensors in health and disease

Baljit S. Khakh et al.

NATURE (2006)

Review Chemistry, Medicinal

P2X receptor ligands and pain

Char-Chang Shieh et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2006)

Review Physiology

Pharmacology of P2X channels

Joel R. Gever et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2006)

Article Biotechnology & Applied Microbiology

Global mapping of pharmacological space

Gaia V. Paolini et al.

NATURE BIOTECHNOLOGY (2006)

Article Chemistry, Medicinal

Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists

Derek W. Nelson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Review Immunology

The P2X7 receptor:: A key player in IL-1 processing and release

Davide Ferrari et al.

JOURNAL OF IMMUNOLOGY (2006)

Review Pharmacology & Pharmacy

The function of microglia through purinergic receptors: Neuropathic pain and cytokine release

K Inoue

PHARMACOLOGY & THERAPEUTICS (2006)

Article Pharmacology & Pharmacy

Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms

RD Beigi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2003)

Review Pharmacology & Pharmacy

Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain

MF Jarvis

EXPERT OPINION ON THERAPEUTIC TARGETS (2003)

Article Chemistry, Medicinal

A comparison of physiochemical property profiles of development and marketed oral drugs

MC Wenlock et al.

JOURNAL OF MEDICINAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

A-317491, a novel potent and selective nonnucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

MF Jarvis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Review Physiology

Molecular physiology of P2X receptors

RA North

PHYSIOLOGICAL REVIEWS (2002)

Review Chemistry, Medicinal

Purine and pyrimidine (P2) receptors as drug targets

KA Jacobson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2002)

Article Immunology

Rapid secretion of interleukin-1β by microvesicle shedding

A MacKenzie et al.

IMMUNITY (2001)