Journal
PURE AND APPLIED CHEMISTRY
Volume 84, Issue 9, Pages 1837-1846Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1351/PAC-CON-12-01-11
Keywords
Brazilian biomes; drug discovery; medicinal chemistry; natural products; tropical biodiversity
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Funding
- FAPESP [03/02176-7]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [03/02176-7] Funding Source: FAPESP
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Natural products are the inspiration for many valuable therapeutic agents and attest to biodiversity being a rich source of new molecular structures. Their value as templates for medicinal chemistry remains undisputed, even after the growth of the combinatorial chemistry era. Tropical environments, such as Brazilian biomes, offer a particularly rich potential for biologically active compounds with unique structures and continue to contribute toward modern drug discovery. Our bioprospecting of plant species of the Cerrado and Atlantic Forest biomes has yielded promising bioactive secondary metabolites, and we describe some of these molecules and semisynthetic derivatives as potential acetylcholinesterase (AChE) inhibitors.
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