Journal
PURE AND APPLIED CHEMISTRY
Volume 82, Issue 11, Pages 1975-1991Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1351/PAC-CON-09-12-15
Keywords
alkaloids; iron; myosin; palladium; silver
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We have developed efficient synthetic routes to heterocyclic ring systems using transition metals (palladium, iron, and silver). Recent applications of this chemistry to the total synthesis of biologically active alkaloids include carbazole alkaloids (pityriazole, euchrestifoline, the antiostatins), crispine A, pentabromo- and pentachloropseudilin. The two latter alkaloids represent a novel class of myosin ATPase inhibitors that led to the discovery of a new allosteric binding site of the protein.
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