Journal
PURE AND APPLIED CHEMISTRY
Volume 82, Issue 7, Pages 1403-1413Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1351/PAC-CON-09-08-17
Keywords
alkyl halides; aryl halides; catalysis; C-H bond activation; copper; palladium; ruthenium
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Palladium catalysts allowed for intermolecular direct arylations of heteroarenes with aryl chlorides, tosylates, or mesylates as electrophiles. As an economically attractive alternative, inexpensive copper catalysts could be employed for regioselective C-H bond arylations of 1,2,3-triazoles. On the contrary, intermolecular C-H bond functionalizations of arenes were accomplished with ruthenium complexes derived from air-stable (heteroatomsubstituted) secondary phosphine oxide (HASPO) preligands. Particularly, the use of ruthenium(II) carboxylate complexes enabled broadly applicable direct arylations with inter alia aryl tosylates and phenols, and set the stage for unprecedented intermolecular direct alkylations with unactivated alkyl halides bearing beta-hydrogens.
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