Journal
PURE AND APPLIED CHEMISTRY
Volume 81, Issue 6, Pages 1051-1063Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1351/PAC-CON-08-10-16
Keywords
natural products; plants; cyanobacteria; fungi; anticancer activity
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Funding
- NCI NIH HHS [P01 CA125066, P01 CA125066-01A1, U19 CA052956] Funding Source: Medline
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A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.
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