Journal
PULMONARY PHARMACOLOGY & THERAPEUTICS
Volume 29, Issue 2, Pages 144-155Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pupt.2014.09.003
Keywords
Asthma; COPD; Airway smooth muscle; Pulmonary fibroblast; Vascular endothelial growth factor; Angiogenesis
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In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review. (C) 2014 Elsevier Ltd. All rights reserved.
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