Journal
PULMONARY PHARMACOLOGY & THERAPEUTICS
Volume 29, Issue 2, Pages 181-198Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pupt.2014.05.008
Keywords
Therapeutic targets; Kinase; G-protein coupled receptor; Transient receptor potential channel; Inflammation; Vitamin D
Categories
Funding
- Medical Research Council (MRC), UK
- National Heart & Lung Institute, UK
- Australian Postgraduate Award
- Stan and Jean Perron PhD Top-Up Scholarship
- Wellcome Trust
- Imperial College London
- MRC
- National Health and Medical Research Council, Australia
- LAM Australasia Research Alliance (LARA), Australia
- Medical Research Council [1252806] Funding Source: researchfish
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Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent respiratory diseases characterized by airway inflammation, airway obstruction and airway hyperresponsiveness. Whilst current therapies, such as beta-agonists and glucocorticoids, may be effective at reducing symptoms, they do not reduce disease progression. Thus, there is a need to identify new therapeutic targets. In this review, we summarize the potential of novel targets or tools, including anti-inflammatories, phosphodiesterase inhibitors, kinase inhibitors, transient receptor potential channels, vitamin D and protease inhibitors, for the treatment of asthma and COPD. (C) 2014 Published by Elsevier Ltd.
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