Journal
PULMONARY PHARMACOLOGY & THERAPEUTICS
Volume 26, Issue 6, Pages 710-715Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pupt.2013.07.003
Keywords
Phenotypes; Asthma; Eosinophilic; Th2; Endotypes
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Asthma is increasingly recognized as a heterogeneous disease. However, identification of different subgroups or phenotypes has been complex and controversial. The convergence of both clinical and statistical approaches to grouping patients and their characteristics, in association with increasing recognition of molecular patterns is now beginning to move the field forward. Integration of efficacy data with targeted molecular therapies will eventually lead to more complete understanding of these molecular phenotypes and eventually lead to the identification of fully defined endoytpes. This process should improve our ability to treat more complex and severe forms of asthma. (C) 2013 Elsevier Ltd. All rights reserved.
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