Journal
CANCER DISCOVERY
Volume 5, Issue 12, Pages 1238-1240Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-15-1275
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- NCI NIH HHS [P30 CA008748] Funding Source: Medline
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Sotillo and colleagues describe the molecular events associated with apparent loss of target antigen expression following CAR T-cell therapy. We propose that broader immune activation is required to prevent outgrowth of tumor antigen escape variants following targeted therapies. (C) 2015 AACR.
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