Journal
PULMONARY PHARMACOLOGY & THERAPEUTICS
Volume 25, Issue 6, Pages 415-419Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pupt.2011.12.003
Keywords
MUC1 mucin; Pseudomonas; Toll-like receptor; Airway infection; Inflammation; Anti-inflammation
Categories
Funding
- NIH [RO1 HL-47125, HL-81825]
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Airway surface fluid contains two layers of mucins consisting mainly of 5 different mucin gene products. While the outer layer contains two gel-forming mucins (MUC5AC and MUC5B) that are tightly associated with various biologically active, defensive molecules, the inner layer contains three membrane-tethered mucins (Mud, MUC4 and MUC16) shed from the apical cell surface. During airway infection, all of these mucins serve as a major protective barrier against pathogens. MUC1 mucin produced by virtually all the surface columnar epithelial cells in the respiratory tract as well as Type II pneumocytes in the alveoli plays an additional, perhaps more critical role during respiratory infection by controlling the resolution of inflammation that is essential to prevent the development of inflammatory lung disease. (C) 2012 Elsevier Ltd. All rights reserved.
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