Journal
PULMONARY PHARMACOLOGY & THERAPEUTICS
Volume 22, Issue 2, Pages 90-96Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pupt.2008.08.003
Keywords
fMRI; Manganese enhanced MRI; Capsaicin; Urge-to-cough; Voluntary cough; Cough suppression
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Funding
- National Health and Medical Research Council of Australia [454776, 350333]
- Angior Family Foundation
- University of Melbourne Sir Randal Heymanson Research Fellowship
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Several indications suggest that supramedullary brain regions receive sensory information from the airways and provide motor control to the brainstem neurons that control coughing. However, the organization of this circuitry has not been described in any detail. In this short review we will discuss how state-of-the-art functional brain imaging techniques in humans and animals will enable unprecedented insights into the supramedullary brain regions that help control coughing. In addition we will describe the likely similarities between cough-related higher brain networks and those involved in the processing of other aversive sensory modalities, such as pain. (c) 2008 Elsevier Ltd. All rights reserved.
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