Journal
PULMONARY PHARMACOLOGY & THERAPEUTICS
Volume 21, Issue 5, Pages 743-754Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pupt.2008.01.010
Keywords
Animal models; Bronchoconstriction; Mucus clearance; Airway inflammation
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Sheep naturally allergic to Ascaris suum antigen have been used to study the pathophysiology of asthma and more recently allergic rhinitis, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The utility of the model as it relates to the study of these diseases is discussed. (c) 2008 Elsevier Ltd. All rights reserved.
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