Journal
PSYCHOPHYSIOLOGY
Volume 49, Issue 3, Pages 345-356Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1469-8986.2011.01306.x
Keywords
Schizotypal personality; Schizophrenia; Functional magnetic resonance imaging; Eye movements
Funding
- Deutsche Forschungsgemeinschaft [Et 31/2-1]
- National Institute for Health Research (NIHR)
Ask authors/readers for more resources
Dimensional models of psychosis assume a continuum between schizotypy and schizophrenia. However, little is known about the overlap in brain functional alterations between schizotypy and schizophrenia. Fifty-four healthy volunteers underwent functional magnetic resonance imaging during an antisaccade task, a measure of cognitive control known to be impaired in schizophrenia, and a prosaccade task. Higher positive schizotypy was correlated with higher antisaccade error rates. Associations between reduced blood oxygenation level dependent signal and higher schizotypy were found during antisaccades in the putamen, thalamus, cerebellum, and visual cortex and during prosaccades in the visual cortex, supplementary eye field, and posterior intraparietal sulcus. These findings show that increased schizotypy is associated with decreased antisaccade performance and reduced brain function in regions also affected in schizophrenia, therefore providing evidence of neurocognitive and neurophysiological overlap between schizotypy and schizophrenia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available