Journal
PSYCHOPHYSIOLOGY
Volume 46, Issue 3, Pages 466-472Publisher
WILEY
DOI: 10.1111/j.1469-8986.2009.00802.x
Keywords
AKAP10; Heart rate variability; A kinase-anchoring protein 2; Autonomic function
Funding
- NIH [K01 MH074766, PO1 HL040962, RO1 HL065137]
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Previous evidence suggests that the dual-specific A kinase-anchoring protein 2 functional polymorphism (AKAP10 (A/G) I646V) influences heart rate (HR) and heart rate variability (HRV) in mice and humans (N=122) with cardiovascular disease. Here, we asked whether this AKAP10 variant predicts HR and HRV in a large sample of healthy humans. Resting HR and short-term time and frequency domain measures of HRV (5 min during paced and unpaced respiration conditions) were assessed in a U.S. community sample (N=1,033) of generally healthy men and women (age 30-54) of European ancestry. Each person was genotyped for the AKAP10 variant. As with previous work, the AKAP10 Val allele predicted greater resting HR (Paced p <.01; Unpaced p <.03) and diminished HRV (Paced ps <.05) suggesting that this variant may modulate the sensitivity of cardiac pacemaker cells to autonomic inputs, possibly conferring risk for arrhythmias and sudden cardiac death.
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