4.4 Review

Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development

Related references

Note: Only part of the references are listed.
Article Behavioral Sciences

Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice

Ilse Gantois et al.

BEHAVIOURAL BRAIN RESEARCH (2013)

Article Genetics & Heredity

The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

Elisabetta Tabolacci et al.

BMC MEDICAL GENETICS (2012)

Article Behavioral Sciences

The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice

M. F. Vinueza Veloz et al.

GENES BRAIN AND BEHAVIOR (2012)

Article Behavioral Sciences

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

C. A. Hoeffer et al.

GENES BRAIN AND BEHAVIOR (2012)

Article Biochemistry & Molecular Biology

Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome

Sally M. Till et al.

HUMAN MOLECULAR GENETICS (2012)

Article Biochemistry & Molecular Biology

Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

Xinglong Wang et al.

JOURNAL OF NEUROCHEMISTRY (2012)

Article Cell Biology

Cytoplasmic RNA-Binding Proteins and the Control of Complex Brain Function

Jennifer C. Darnell et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

Article Psychology, Developmental

Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment

Stephanie M. Sansone et al.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2012)

Article Biochemistry & Molecular Biology

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

Jennifer C. Darnell et al.

Review Chemistry, Medicinal

mGluR5 Negative Allosteric Modulators Overview: A Medicinal Chemistry Approach Towards a Series of Novel Therapeutic Agents

Jean-Philippe Rocher et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning

Weixiang Guo et al.

NATURE MEDICINE (2011)

Article Multidisciplinary Sciences

Genetic-Background Modulation of Core and Variable Autistic-Like Symptoms in Fmr1 Knock-Out Mice

Susanna Pietropaolo et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

Dilja D. Krueger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein

Der-I Kao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

Potential therapeutic interventions for fragile X syndrome

Josien Levenga et al.

TRENDS IN MOLECULAR MEDICINE (2010)

Review Genetics & Heredity

The FMR1 Gene and Fragile X-Associated Tremor/Ataxia Syndrome

J. R. Brouwer et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2009)

Review Behavioral Sciences

Social approach in genetically engineered mouse lines relevant to autism

S. S. Moy et al.

GENES BRAIN AND BEHAVIOR (2009)

Article Biochemistry & Molecular Biology

Fragile X Mental Retardation Protein Regulates the Levels of Scaffold Proteins and Glutamate Receptors in Postsynaptic Densities

Janin Schuett et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Genetics & Heredity

A pilot open label, single dose trial of fenobam in adults with fragile X syndrome

E. Berry-Kravis et al.

JOURNAL OF MEDICAL GENETICS (2009)

Article Multidisciplinary Sciences

Generation and Characterization of Fmr1 Knockout Zebrafish

Marjo J. den Broeder et al.

PLOS ONE (2009)

Article Genetics & Heredity

A Mouse Model of the Human Fragile X Syndrome I304N Mutation

Julie B. Zang et al.

PLOS GENETICS (2009)

Article Behavioral Sciences

Evidence for social anxiety and impaired social cognition in a mouse model of Fragile X syndrome

Caitlyn H. McNaughton et al.

BEHAVIORAL NEUROSCIENCE (2008)

Article Biochemistry & Molecular Biology

Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations

Elisabetta Tabolacci et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2008)

Article Biochemistry & Molecular Biology

Fragile X syndrome

Kathryn B. Garber et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2008)

Article Behavioral Sciences

Open-label treatment trial of lithium to target the underlying defect in fragile X syndrome

Elizabeth Berry-Kravis et al.

JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS (2008)

Article Neurosciences

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

Fernke M. S. de Vrij et al.

NEUROBIOLOGY OF DISEASE (2008)

Article Biotechnology & Applied Microbiology

Modest reactivation of the mutant FMR1 gene by valproic acid is accompanied by histone modifications but not DNA demethylation

Elisabetta Tabolacci et al.

PHARMACOGENETICS AND GENOMICS (2008)

Article Neurosciences

Correction of fragile X syndrome in mice

Gul Dolen et al.

NEURON (2007)

Article Biochemistry & Molecular Biology

Elevated FMR1 mRNA in premutation carriers is due to increased transcription

Flora Tassone et al.

Article Neurosciences

Decreased expression of the GABAA receptor in fragile X syndrome

Charlotte D'Hulst et al.

BRAIN RESEARCH (2006)

Review Pharmacology & Pharmacy

Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis

Gurpreet K. Dhami et al.

PHARMACOLOGY & THERAPEUTICS (2006)

Article Neurosciences

The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo

EJ Mientjes et al.

NEUROBIOLOGY OF DISEASE (2006)

Article Behavioral Sciences

Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome

CM Spencer et al.

GENES BRAIN AND BEHAVIOR (2005)

Article Multidisciplinary Sciences

Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome

L Restivo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments

E Tabolacci et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2005)

Article Neurosciences

Decreased GABAA receptor expression in the seizure-prone fragile X mouse

A El Idrissi et al.

NEUROSCIENCE LETTERS (2005)

Article Cell Biology

Characterisation of Fmrp in zebrafish:: evolutionary dynamics of the fmr1 gene

S van 't Padje et al.

DEVELOPMENT GENES AND EVOLUTION (2005)

Article Biochemistry & Molecular Biology

Transport of fragile X mental retardation protein via granules in neurites of PC12 cells

YD Otero et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Genetics & Heredity

Timing of the absence of FMR1 expression in full mutation chorionic villi

R Willemsen et al.

HUMAN GENETICS (2002)

Article Multidisciplinary Sciences

Altered synaptic plasticity in a mouse model of fragile X mental retardation

KM Huber et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Neurosciences

Fragile X mice develop sensory hyperreactivity to auditory stimuli

L Chen et al.

NEUROSCIENCE (2001)

Article Biochemistry & Molecular Biology

(Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features

AM Peier et al.

HUMAN MOLECULAR GENETICS (2000)