Journal
BIOMEDICAL OPTICS EXPRESS
Volume 6, Issue 12, Pages 5021-5032Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.6.005021
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Funding
- German Research Foundation (Cluster of Excellence: Munich Centre for Advanced Photonics) [DFG-HU 1006/2, HU 1006/3]
- European Union (ERC) [259158]
- European Research Council (ERC) [259158] Funding Source: European Research Council (ERC)
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Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called Heartbeat OCT, combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one cardiac cycle. We acquired in vivo data sets of two coronary arteries in a porcine heart with both Heartbeat OCT, working at 2.88 MHz A-line rate, 4000 frames/s and 100 mm/s pullback speed, and with a commercial system. The in vivo results show that Heartbeat OCT provides faithfully rendered, motion-artifact free, fully sampled vessel wall architecture, unlike the conventional IV-OCT data. We present the Heartbeat OCT system in full technical detail and discuss the steps needed for clinical translation of the technology. (C) 2015 Optical Society of America
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