4.6 Article

Broadband miniature optical ultrasound probe for high resolution vascular tissue imaging

Journal

BIOMEDICAL OPTICS EXPRESS
Volume 6, Issue 4, Pages 1502-1511

Publisher

OPTICAL SOC AMER
DOI: 10.1364/BOE.6.001502

Keywords

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Funding

  1. EPSRC [EP/J010952/1]
  2. European Research Council [310970]
  3. European Union [317744]
  4. University College London-Cambridge University Photonic Systems Development Centre for Doctoral Training
  5. EPSRC [EP/J010952/1, EP/L002019/1, EP/H005536/1] Funding Source: UKRI
  6. Engineering and Physical Sciences Research Council [EP/H005536/1, EP/J010952/1, EP/L002019/1, 1205028] Funding Source: researchfish
  7. European Research Council (ERC) [310970] Funding Source: European Research Council (ERC)

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An all-optical ultrasound probe for vascular tissue imaging was developed. Ultrasound was generated by pulsed laser illumination of a functionalized carbon nanotube composite coating on the end face of an optical fiber. Ultrasound was detected with a Fabry-Perot (FP) cavity on the end face of an adjacent optical fiber. The probe diameter was < 0.84 mm and had an ultrasound bandwidth of similar to 20 MHz. The probe was translated across the tissue sample to create a virtual linear array of ultrasound transmit/receive elements. At a depth of 3.5 mm, the axial resolution was 64 mu m and the lateral resolution was 88 mu m, as measured with a carbon fiber target. Vascular tissues from swine were imaged ex vivo and good correspondence to histology was observed. (C) 2015 Optical Society of America

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